Seventh HIV Remission Sparks Hope, and Raises Questions About U.S. LeadershipOriginal reporting by Michelle Starr, Nature
A German man known as “Berlin 2 (B2)” has remained in remission from HIV for six years after a stem cell transplant to treat leukemia. This marks the seventh known case of long-term HIV remission worldwide. Unlike earlier cases, B2’s donor carried only one copy of the CCR5 Δ32 mutation, previously thought insufficient for durable resistance. His remission challenges assumptions and opens new pathways for understanding how HIV reservoirs can be eliminated. Globally, 40.8 million people were living with HIV in 2024, with 1.3 million new infections and 630,000 AIDS-related deaths. In the U.S., 39,201 new diagnoses were reported in 2023, disproportionately impacting Black and Latino communities, especially in the South. These breakthroughs abroad raise urgent questions: For those living with HIV/AIDS, these questions are not abstract, they are about survival. If you are reading this and living with HIV, ask your doctor about the current status of cure research. Demand transparency. Stem cell transplants are not scalable cures, but they prove that reservoir reduction, graft-versus-reservoir responses, and partial CCR5 protection can lead to remission. The challenge now is whether America will invest in replicating these mechanisms through gene editing and pharmaceutical innovation or continue to let others lead while its citizens wait.
